PhD (1991) UQAM
 

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Marc-André Bédard

1 | Aperçu de Recherche

Marc-André Bédard utilise des approches pharmacologiques et d'imagerie nucléaire cérébrale (PET et SPECT) afin de mieux caractériser les contributions de divers systèmes neurochimiques dans les fonctions cognitives ou maladies neurodégénératives impliquant les noyaux gris centraux. Ses intérêts plus spécifiques sont :

  1. La contribution respective des lésions tegmentaires cholinergiques (noyaux pédonculopontins et latérodorsaux) et dopaminergiques (substance noire compacte et aire tegmentaire ventrale) dans les troubles cognitifs de la maladie de Parkinson, la démence à corps de Lewy et autres syndromes apparentés;
  2. La relation entre le profil pharmacologique des neuroleptiques et l'apprentissage sensori-moteur chez le patient schizophrène.
  3. Le rôle du système dopaminergique nigro-strié dans l'apprentissage sensori-moteur chez le primate.

2 | Publications Récentes

Rockwood K, Black, S, Bédard, MA, Gold, D., Lussier I. (2006) Clinical meaningfulness of symptom changes associated with donepezil treatment of Alzheimer’s disease: A multi-centre, primary care, open label study. International Journal of Geriatric Psychiatry (sous presse).

Bédard, M.-A. (2004) « Neurotransmetteurs et neuropsychologie ». In: B. Lechevalier, F. Eustache & F. Viader (Eds.) TRAITE DE NEUROPSYCHOLOGIE CLINIQUE. Bruxelles: Editions De Boeck, (sous presse)

Gagnon JF, Fantini ML, Bédard MA, Petit D, Rompré S, Carrier J, Panisset M, Décary A & Montplaisir J. (2004). Association between waking EEG slowing and REM sleep behavior disorder in Parkinson's disease without dementia. Neurology 62 : 401-406.

Lemay, S., Chouinard, S., Blanchet, P., Masson, H., Soland V., Beuter, A.,& Bédard, M.-A. (2004) Lack of Efficacy of a Nicotine Transdermal Treatment on Motor and Cognitive Deficits in Parkinson’s Disease, Progress in neuropsychopharmacology and biological psychiatry, 28: 31-39.

Schérer, H., Stip, E., Paquet, F., Rodriguez, J.P., Motard, J.P., Bédard, M.-A. (2004) Procedural learning in schizophrenia can reflect the pharmacological properties of the antipsychotic treatments. Cognitive and Behavioral Neurology, 17(1): 32-40.

Paquet, F., Lévesque, M., Soucy, J.P., Elie, A., Stip, E., Archambault-Grenier, M-A., Bédard, M.A. (2004) Comparison between olanzapine and haloperidol on the procedural learning and relationship with the striatal D2 receptor occupancy in schizophrenia. Journal of Neuropsychiatry and clinical neurosciences, 16(1): 47-56.

Semkovska M., Bédard, M.-A., Stip, E. (2004) Assessment of executive dysfunction during activities of daily living in schizophrenia. Schizophrenia Research, Aug 1; 69(2-3): 289-300.

Schérer, H., Paquet, F., Stip, E. & Bédard, M.-A. (2003) Mild procedural learning disturbances in neuroleptic-naive patients with schizophrenia. Journal of Neuropsychiatry and clinical neurosciences, 15:58-63.

Bédard, M.-A., Lévesque, M., Lemay, S., Paquet, F. (2003) « Non-Dopaminergic Influences on Cognition in Parkinson’s Disease ». In: M.-A. Bédard, Y. Agid, S. Chouinard, S. Fahn, A. Korczyn & P. Lespérance (Eds.) MENTAL AND BEHAVIORAL DYSFUNCTION IN MOVEMENT DISORDERS. Totowa NJ: Editions Humana Press, pp. 201-211 .

Paquet, F., Soucy, J.P., Elie, A., Stip, E., Cheneval, E., Bédard, M.A. (2003) Comparison between olanzapine and haloperidol on the procedural learning and on the striatal D2 receptor binding in schizophrenia : a SPECT study using 123I-IBZM. Journal of Neuropsychiatry and clinical neurosciences.

Lemay, S., Blanchet, P, Chouinard, S, Soland V, Masson, H,& Bédard, M.-A. (2003) Poor Tolerability of a Transdermal Nicotine Treatment in Parkinson's Disease, Clinical Neuropharmacology, 26: 227-229.

Semkovska, M., Stip, E., Godbout, L., Paquet, F., Bédard, M. -A. (2002). Behavioral Disorganization in Schizophrenia During a Daily Activity: The Kitchen Behavioral Scoring Scale. Brain and Cognition, 48, 546-553.

Duchesne, N., Soucy, J.-P., Masson, H., Chouinard, S., Bédard, M.-A. (2002) Cognitive deficits and striatal dopaminergic denervation in Parkinson's disease: a SPECT study using Iodine123- b-CIT in patients ON and OFF levodopa. Clinical Neuropharmacology, 25 :216-224.

Duchesne, N., Soucy, J.-P., Masson, H., Chouinard, S., Bédard, M.-A. (2002) Cognitive deficits and striatal dopaminergic denervation in Parkinson’s disease: a SPECT study using Iodine123- b-CIT in patients ON and OFF levodopa. Clinical Neuropharmacology, 25 :216-224.

Gagnon, J.F., Montplaisir, J., Bédard, M.-A. (2002) Les troubles du sommeil paradoxal dans la maladie de Parkinson. Revue de Neurologie (Paris), 158 :2,135-152.

Gagnon, J.F., Bédard, M.-A., Fantini, M.-L., Petit, D., Panisset, M., Rompré, S., Carrier, J., Montplaisir, J. (2002) REM sleep behavior disorders and REM sleep without atonia in Parkinson's disease. Neurology,59 :585-589.

Rouleau, I., Imbault, H., Laframboise, M. & Bédard, M.-A. (2001). Pattern of intrusions in verbal recall: Comparison of Alzheimer's disease, Parkinson's disease and frontal lobe dementia. Brain & cognition, 46 :244-249.

Semkovska, M., Bédard, M.-A., Stip, E. (2001) Hypofrontality and negative symptoms in schizophrenia: synthesis of anatomic and neuropsychological knowledge and ecological perspectives. Encephale, 27:405-415.

Bédard, M.-A. (2000) « Cognitive Disorders in Parkinson ‘s Disease ». Brochure de la Collection « Dopamine », écrit pour la compagnie pharmaceutique « Servier International », 40pp.

Bédard, M.-A., Schérer, H., Stip, E., Cohen, H., Rodriguez J.P. & Richer, F. (2000) Procedural learning in schizophrenia : Further consideration on the deleterious effect of neuroleptics. Brain & Cognition, 43 : 31-39.

Black, D.N., Stip, E., Bédard, M.-A., Kabay, M., Paquette, I. & Bigras, M.-J. (2000) Leukotomy revisited : Late cognitive and behavioral effects in chronic institutionalized schizophrenics. Schizophrenia Research, 43:57-64.